One-Year Evaluation of Combined Treatment with an Intranasal Corticosteroid and Montelukast for Chronic Rhinosinusitis Associated with Asthma
نویسندگان
چکیده
منابع مشابه
One-year evaluation of combined treatment with an intranasal corticosteroid and montelukast for chronic rhinosinusitis associated with asthma.
OBJECTIVES Chronic rhinosinusitis associated with asthma is often difficult to treat effectively with intranasal corticosteroids alone. Thus, the aim of this study was to evaluate the effectiveness of combination treatment with an intranasal corticosteroid and a leukotriene-receptor antagonist (montelukast) in reducing the size of nasal polyps. METHODS The subjects of this study were 20 patie...
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BACKGROUND Cysteinyl leukotrienes (CysLT) are a class of inflammatory mediators synthesized by eosinophils and mast cells through the breakdown of arachidonic acid. They are known to play a key role in the molecular pathophysiology of asthma and chronic rhinosinusitis (CRS), promoting bronchoconstriction, mucus production, edema, and chemotaxis of neutrophils and eosinophils. Indeed, upregulati...
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ژورنال
عنوان ژورنال: Journal of Nippon Medical School
سال: 2010
ISSN: 1345-4676,1347-3409
DOI: 10.1272/jnms.77.21